Screening designs for drug development

Screening designs for drug development.

We propose drug screening designs based on a Bayesian decision-theoretic approach. The discussion is motivated by screening designs for phase II studies. The proposed screening designs allow consideration of multiple treatments simultaneously. In each period, new treatments can arise and currently considered treatments can be dropped. Once a treatment is removed from the phase II screening tria...

New Platforms For Drug Screening And Toxicology: Necessity Or Need?

The liver is the largest internal organ in the human body that is responsible for more than 500 vital functions, including biosynthesis of major plasma proteins, immunity against infectious pathogens, balancing energy metabolism and xenobiotics biotransformation (1). One of the main functions of the liver is an important role in drug metabolism (2). Since developing new drug compounds into mark...

***Removed from the Issue*** Application of Cell-Based Assay Systems for the Early Screening of Human Drug Hepatotoxicity in the Discovery Phase of Drug Development

Screening by Conference Designs

Screening experiments are addressed to the identiication of the relevant variables within some process or experimental outcome potentially depending on a large number of variables. In this paper we introduce a new class of experimental designs called edge designs. These designs are very useful for screening experiments since they allow a model-independent estimate of the set of relevant variabl...

Withdrawing of Article ''Application of Cell-Based Assay Systems for the Early Screening of Human Drug Hepatotoxicity in the Discovery Phase of Drug Development''